Why You’re Gaining Weight in Midlife: Ozempic, Muscle Loss, and Longevity | Dr. Mary Pardee

Midlife weight gain is often blamed on a “slowing metabolism.” But the science tells a different story. Between ages 20 and 60, your metabolism barely changes. What does change? Muscle mass. Exercise habits. Hormonal signaling. Cardiovascular risk. And increasingly, the conversation around GLP-1 medications like Ozempic. In this episode, we unpack the real drivers of midlife weight gain, the surprising data on muscle loss and mortality, the nuanced role of GLP-1 drugs in long-term health, and what actually improves lifespan and healthspan. If you’ve wondered: Is my metabolism broken? Is Ozempic helping or hurting long term? Why is muscle suddenly such a big deal? What actually prevents heart disease and dementia? This episode connects the dots. Learn more about your ad choices. Visit megaphone.fm/adchoices