Mental Health, Depression & Autoimmune Disease: The Vagus Nerve Connection

In this episode, Dr. Micah Yu and Dr. Melissa Mondala discuss one of the most overlooked aspects of autoimmune disease: mental health. With depression and anxiety affecting more than half of all autoimmune patients, the conversation explores the deep connection between the nervous system, trauma, inflammation, and long-term healing. Key Points: One in two people with autoimmune disease also has depression or anxiety. Mental health symptoms often appear years before autoimmune diagnosis. Emotional trauma, chronic stress, and neuroinflammation can all trigger or worsen autoimmune flares. The field of psycho-neuro-immunology explains how the brain, nervous system, and immune system interact. Childhood trauma (ACEs) significantly increases the risk of autoimmune conditions later in life. Early signs of depression and anxiety include sleep changes, appetite issues, mood swings, perfectionism, joint pain, rashes, and fatigue. Root Causes of Mental Health + Autoimmune Disease: Chronic stress and trauma Hormonal fluctuations (e.g., PMS, menopause) Neurotransmitter imbalances Gut and microbiome dysfunction Environmental toxins and heavy metals Nutrient deficiencies (zinc, B vitamins, etc.) Treatment Strategies: Nutrition: Whole foods rich in omega-3s, zinc, tryptophan, tyrosine, antioxidants Lifestyle: Daily movement, quality sleep, community connection Practices: Meditation, prayer, breathwork, vagus nerve activation (humming, singing) Supplements (under guidance): SAM-e, L-theanine, ashwagandha, tryptophan Psychotherapy, psychosomatic healing, and nervous system retraining Featured Case Study: A 60-year-old woman with long-standing rheumatoid arthritis saw dramatic improvement in pain, energy, and inflammation after focusing on nervous system regulation, sleep, and mental wellness. Her care plan included vagus nerve stimulation and lifestyle changes. Within 3 months, she was pain-free, off prednisone, and considering a return to nursing. Her recovery also positively impacted her son, who struggled with mental health issues. Final Message: Healing is possible — even after years of trying. When diet and medications aren’t enough, it’s time to address mental health, trauma, and the nervous system. This episode reminds us that what feels emotional is often physical, and that support, persistence, and the right tools can make all the difference. Learn more or schedule a consult: Dr. Yu and Dr. Mondala’s clinic: https://myautoimmunemd.com Dr. Yu on YouTube: My Autoimmune MD Dr. Mondala on YouTube & Instagram: Dr. Melissa’s Kitchen